J. Yasha Kresh, PhD: Cardiothoracic Surgery – Drexel University-6415
Nội dung bài viết:
Myocardial infarction and heart failure are characterized by maladaptive remodeling of the cardiac tissue wall and are often accompanied by diffuse fibrosis.
The overarching hypothesis is that remodeling and reorganization of the myocyte-cytoskeletal (CSK) architecture is a collective (structurally integrative) process, requiring instructive extracellular signals (e.g., cell-ECM and cell-cell contact).
It is becoming increasingly clear that changes in cardiac function accompanying tissue remodeling associated with heart failure are brought about by the disruption of the mechanotransduction continuum (e.g., disorganized cells alignment and altered cell phenotype). The ability to surgically engineer (reverse remodel) the mechanical milieu of cells provides a compelling rationale for advancing novel biomaterial-based therapeutic strategies (e.g., injectable scaffolds).
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